Arbutus regains global rights to imdusiran following Qilu exit

27 June 2025

US biotech Arbutus Biopharma (Nasdaq: ABUS) has reacquired the rights to its lead hepatitis B candidate, imdusiran (AB-729), in China, ending a nearly four-year partnership with Qilu Pharmaceutical.

The companies confirmed the move in a joint agreement this week, with Arbutus citing a strategic focus on accelerating its chronic hepatitis B pipeline and Qilu pointing to internal reprioritization. While the financial terms of the reacquisition were not disclosed, the original 2021 deal had included a $40 million upfront payment and the potential for up to $245 million in milestone payouts.

Arbutus, now under the leadership of chief executive Lindsay Androski, has spent recent months reorienting its operations around imdusiran. That included halting all in-house research and laying off more than half its workforce, while also vacating its Warminster, Pennsylvania, headquarters.

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