AstraZeneca delivering on many fronts with next-generation propellant

23 September 2025

In May of this year, AstraZeneca’s (LSE: AZN) Trixeo Aerosphere (budesonide/glycopyrronium/formoterol fumarate) - already licensed to treat chronic obstructive pulmonary disease (COPD) in adults - was approved for use in the UK with an innovative, next-generation propellant with near-zero global warming potential (GWP).

Marketed as Breztri Aerosphere in the USA, China and Japan, it is the first medicine delivered by a pressurized metered-dose inhaler (pMDI) approved with the propellant that has 99.9% lower GWP than propellants used in currently available pMDIs. 

Trixeo with the next-generation propellant will have a low carbon footprint, comparable to inhaled medicines that do not require a propellant.

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