AstraZeneca scores second Phase III win with baxdrostat in resistant hypertension

7 October 2025

AstraZeneca (LSE: AZN) has reported positive top-line results from its second Phase III trial of baxdrostat, showing the oral therapy cut blood pressure significantly in patients with treatment-resistant hypertension.

Baxdrostat is designed to lower blood pressure by selectively inhibiting aldosterone, a hormone that drives cardiovascular and renal risk. Importantly, Phase I studies showed the drug peaks in the bloodstream within hours and sustains activity with a half-life approaching 30 hours.

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