DelveInsight sees Graves’ orbitopathy market poised for disruption as new drugs approach

3 October 2025

The Graves’ orbitopathy treatment market was worth $2.1 billion in 2024 across leading regions, with the USA accounting for 96% of sales, according to a new DelveInsight report.

Amgen’s (Nasdaq: AMGN) Tepezza (teprotumumab-trbw) remains the only approved drug for now, generating $1.85 billion in revenue in 2024, underscoring its dominant position.

Tepezza’s patent protection gives Amgen a temporary moat, but looming launches threaten its near-monopoly. Analysts expect newcomers to carve out share by offering more convenient subcutaneous dosing or better tolerability. A positive scientific opinion this year has also opened the door for Tepezza in Europe, expanding the market.

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