Despite top-line trial success, Compass going in wrong direction

23 June 2025

Psychedelic medicines company Compass Pathways (Nasdaq: CMPS) was trading 46% lower midday Monday.

The UK-based firm earlier announced that it had met the primary endpoint in the ongoing 258-patient Phase III COMP005 trial, the first of two Phase III trials evaluating COMP360, a synthetic, proprietary formulation of psilocybin, for treatment-resistant depression (TRD).

The primary endpoint is the difference in change from baseline in the Montgomery-Åsberg depression rating scale (MADRS) scores between the active treatment group and the placebo group at week six. 

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