Gilead’s twice-yearly lenacapavir shows 100% efficacy and bests Truvada for HIV prevention

20 June 2024

Gilead Sciences (Nasdaq: GILD) shares were up 7.6% at $67.96, as the US antivirals major released positive trial data.

Gilead announced top-line results from an interim analysis of its pivotal, Phase III PURPOSE 1 trial indicating that the company’s twice-yearly injectable HIV-1 capsid inhibitor, lenacapavir, demonstrated 100% efficacy for the investigational use of HIV prevention in cisgender women.

PURPOSE 1 met its key efficacy endpoints of superiority of twice-yearly lenacapavir to Gilead's once-daily oral Truvada (emtricitabine 200mg and tenofovir disoproxil fumarate 300mg; F/TDF) and background HIV incidence (bHIV). Based on these results, the independent Data Monitoring Committee (DMC) recommended that Gilead stop the blinded phase of the trial and offer open-label lenacapavir to all participants.

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