Hopes to add to Venclexta/Venclyxto label dashed

17 June 2025

Pharma majors AbbVie (NYSE: ABBV) and Roche (ROG: SIX) were both trading lower early Tuesday after top-line results were announced from the global Phase III VERONA trial.

AbbVie revealed that the study - - evaluating Venclexta/Venclyxto (venetoclax) alongside azacitidine in the treatment of newly diagnosed higher-risk myelodysplastic syndrome (HR-MDS) - did not meet the primary endpoint of overall survival (OS).

The medicine, which selectively binds and inhibits the B-cell lymphoma-2 (BCL-2) protein, is currently approved for certain patients with acute myeloid leukaemia, chronic lymphocytic leukaemia and small lymphocytic lymphoma.

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