Intercell's Travelers' diarrhea vaccine and Lilly's tasisulam flop; Amgen's Xgeva looks good
Austria-headquartered Intercell AG (VSE: ICLL) saw its shares plunge 41% to 10 euros by close of trading in Vienna, slashing the company’s market capitalization to 485.9 million euros ($642.4 million), after it revealed that it would drop development of its Travellers’ diarrhea vaccine candidate after it failed in two studies.
The decision was made following the receipt of results of its randomized and placebo-controlled Phase III study (ELT301) with 2036 travelers from Europe to Mexico and Guatemala as well as the pilot efficacy Phase II trial (ELT209) with 723 travelers from Europe to India.
The Travelers' diarrhea vaccine candidate failed to meet efficacy endpoints to protect against enterotoxigenic E. coli (ETEC) (defined as cases in which ETEC LT, LT/ST or ST toxins are detected in diarrheal stool samples) mediated diarrheal infections in pivotal, randomized and placebo-controlled efficacy studies (Phase II and Phase III).
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