Nuvalent rises on positive neladalkib trial findings

18 November 2025

Shares of US clinical-stage biopharmaceutical company Nuvalent (Nasdaq: NUVL) jumped more than 15% to $111.22 by midday yesterday, after it announced positive top-line pivotal data for neladalkib.

The investigational drug is an ALK-selective inhibitor, in tyrosine kinase inhibitor (TKI) pre-treated patients with advanced ALK-positive non-small cell lung cancer (NSCLC) in the global ALKOVE-1 Phase I/II clinical trial.

Additionally, the company shared the first report of preliminary data from the Phase II exploratory cohort for TKI-naïve patients with advanced ALK-positive NSCLC from the ALKOVE-1 study.

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