Positive Phase II results for Alkermes’ alixorexton

13 November 2025

Ireland-based Alkermes (Nasdaq: ALKS) has announced positive top-line results from the Vibrance-2 dose-ranging Phase II study evaluating alixorexton in patients with narcolepsy type 2 (NT2).

Alixorexton, formerly referred to as ALKS 2680, is the company's novel, investigational, oral, selective orexin 2 receptor (OX2R) agonist in Phase II development for the treatment of narcolepsy type 1 (NT1), NT2 and idiopathic hypersomnia (IH).

Despite the seemingly positive news, Alkermes' share price fell about 8% on Wednesday as investors digested the results, which came in below analyst expectations for the highest dose of alixorexton.

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