Positive results for Zealand’s GLP-1/GLP-2 receptor dual agonist dapiglutide
Zealand Pharma (Nasdaq: ZEAL), a Danish firm focused on the discovery and development of innovative peptide-based medicines, has announced positive top-line results from part two of a Phase Ib multiple ascending dose (MAD) trial investigating 28 weeks of treatment with dapiglutide, a long-acting GLP-1/GLP-2 receptor dual agonist.
Body weight reductions of a mean of 11.6% after 28 weeks with dapiglutide escalated up to 26 mg, with 95% of trial participants being male, a median baseline BMI of 28.5 kg/m2, and no lifestyle modifications.
Treatment with dapiglutide was assessed to be safe and well-tolerated with gastrointestinal adverse events consistent with the profile reported with other incretin-based therapies.
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