Roche punts up to $3.5B to acquire 89bio

18 September 2025

California, USA-based liver specialist 89bio (Nasdaq: ETNB) saw its shares rocket more than 83% to $14.83 in pre-market activity on the news of a takeover deal by Roche (ROG: SIX).

This is the first US acquisition by a Swiss pharmaceuticals company since the Trump administration hit the country with the highest tariffs in Europe.

The main attraction is 89bio’s pegozafermin, a FGF21 analog currently in late-stage development for metabolic dysfunction-associated steatohepatitis (MASH) in moderate and severe fibrotic patients (F2 and F3 stages) as well as cirrhotic patients (F4 stage).

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