Spero Therapeutics rockets on positive Phase III study for tebipenem HBr

29 May 2025

Spero Therapeutics (Nasdaq: SPRO) is making headlines as its stock experienced a remarkable 244% surge to $2.35 yesterday, on news of positive clinical trial results.

The Cambridge, USA-based company and UK pharma major GSK (LSE: GSK) announced that the pivotal Phase III PIVOT-PO trial evaluating tebipenem HBr, an investigational oral treatment for complicated urinary tract infections (cUTIs), including pyelonephritis, met its primary endpoint and will stop early for efficacy.

The decision follows a recommendation from an Independent Data Monitoring Committee (IDMC) that completed a pre-specified interim analysis of data from 1,690 patients enrolled in the trial.

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