Syndeio debuts with $90 million and a synapse-first approach

27 May 2025

US biotech Syndeio Biosciences has launched with over $90 million in funding and a pipeline of synapse-targeting neurotherapies aimed at treating major depressive disorder, Alzheimer’s disease, and other central nervous system (CNS) conditions.

Backed by a syndicate of life science investors including Catalio Capital Management, Innoviva, Tenmile, Luson Bioventures, and Palo Santo, Syndeio also lists AbbVie (NYSE: ABBV) and Eli Lilly (NYSE: LLY) as strategic shareholders.

The company’s lead candidate, zelquistinel, is currently enrolling a Phase II study in major depressive disorder and is expected to enter a first-of-its-kind biomarker-driven trial in Alzheimer’s disease later this year.

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