US drugmaker Vertex Pharmaceuticals (Nasdaq: VRTX) has announced data across multiple studies demonstrating positive clinical and quality of life benefits of treatment with cystic fibrosis transmembrane conductance regulator (CFTR) modulators and, in particular, its Alyftrek (vanzacaftor/tezacaftor/deutivacaftor).
The cystic fibrosis drug is approved in the USA and UK and is currently under review with health authorities in the EU, Canada, Australia, New Zealand and Switzerland. It generated first-quarter 2025 sales of $54 million, way behind Vertex’ leading CF therapy Trikafta (elexacaftor/tezacaftor/ivacaftor), which recorded 42.54 billion revenues in the sae period.
These data were presented at this year’s European Cystic Fibrosis Society’s (ECFS) 48th European Cystic Fibrosis Conference held June 4-7, 2025, in Milan, Italy.
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