Phase II laru-zova trial win for Beacon

6 December 2024

Ophthalmic gene therapy company Beacon Therapeutics Holdings has announced the presentation of three-month interim safety and efficacy results of AGTC-501 (laruparetigene zovaparvovec; laru-zova) in the Phase II DAWN trial in patients with X-linked retinitis pigmentosa (XLRP at the FLORetina-ICOOR Meeting 2024 in Florence, Italy.

Beacon Therapeutics, which was launched last year by British life science incubator Syncona (LSE: SYNC), noted that key highlights of the trial showed:

  • The three-month data show that laru-zova has been well-tolerated by all participants.
  • No study agent-related treatment emergent adverse events (TEAEs) were reported, including no ocular inflammatory adverse events.
  • Data also show promising early improvements in LLVA, a critical measure of visual function.
  • The benefit-risk profile supports on-going clinical development for the treatment of patients with XLRP caused by RPGR mutations.

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