Phase III trial shows substantial survival advantage for Imdelltra

11 April 2025

US biotech giant Amgen (Nasdaq: AMGN) today announced a significant breakthrough with its global Phase III DeLLphi-304 clinical trial evaluating Imdelltra (tarlatamab-dlle).

The study is investigating the drug as a treatment for patients with small cell lung cancer (SCLC) who progressed on or after a single line of platinum-based chemotherapy met its primary endpoint at a planned interim analysis.

Imdelltra demonstrated statistically-significant and clinically-meaningful improvement in overall survival (OS) compared to local standard-of-care (SOC) chemotherapy.

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