Positive new data for Keytruda with Phase III trial in ovarian cancer

15 May 2025

US pharma giant Merck & Co (NYSE: MRK) today announced that the Phase III KEYNOTE-B96 trial, also known as ENGOT-ov65, met its primary endpoint of progression-free survival (PFS) for the treatment of patients with platinum-resistant recurrent ovarian cancer whose tumors expressed PD-L1 and in all comers.

The study also met a secondary endpoint of overall survival (OS) in patients whose tumors express PD-L1.

The study is evaluating Keytruda (pembrolizumab), Merck’s mega blockbuster anti-PD-1 therapy, in combination with chemotherapy (paclitaxel) with or without bevacizumab for these patients. The trial is continuing and OS for the full study population will be evaluated at a future analysis.

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