Potent adjuvant activity for Nventa's Poly-ICR in preclinical studies
The USA's Nventa Biopharmaceuticals presented positive data from preclinical studies using its proprietary Toll-like Receptor 3 agonist, Poly IC-Poly Arginine, at the World Vaccine Congress, held in Lyon, France.
Results demonstrated Poly-ICR to be a potent vaccine adjuvant. In combination with model antigens, it elicits strong anti-target antibody and CD8 T-cell immune responses that suggest the compound may possess broad potential for use in both therapeutic and prophylactic vaccines.
According to Nventa, Poly-ICR is stable and resistant to degradation by RNAses in human serum, induces significant cytokine and chemokine production and matures dendritic cells.
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