Regeneron delivers reminder of Libtayo potential in non-melanoma skin cancers
US biotech Regeneron Pharmaceuticals (Nasdaq: REGN) has announced detailed analyses from the Phase III C-POST trial, which evaluated PD-1 inhibitor Libtayo (cemiplimab) in patients with high-risk cutaneous squamous cell carcinoma (CSCC) after surgery.
The results, shared during an oral session at the 2025 American Society of Clinical Oncology (ASCO) Annual Meeting and simultaneously published in the New England Journal of Medicine (NEJM), include additional data for the primary endpoint of disease-free survival (DFS) and the first presentation of key secondary endpoint outcomes.
Libtayo demonstrated a 68% drop in the risk of disease recurrence or death, the primary endpoint of the trial. It also led to 80% and 65% reductions in the risk of locoregional and distant recurrence, respectively, compared to placebo.
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