Rhythm’s setmelanotide cuts BMI by 20%

8 April 2025

US biopharma Rhythm Pharmaceuticals (Nasdaq: RYTM) has announced positive topline results from the pivotal Phase III TRANSCEND trial evaluating setmelanotide, a melanocortin-4 receptor (MC4R) agonist, for the treatment of acquired hypothalamic obesity.

Shares in Rhythm were around 14% higher during Tuesday’s early trading.

The global trial met its primary endpoint with a statistically significant and highly clinically meaningful reduction in body mass index (BMI) with setmelanotide in both adult and pediatric patients versus placebo.

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