Japan's Shionogi says that two distinct year-long studies of velneperit, a novel neuropeptide Y (NPY) Y5 receptor antagonist also known as S-2367, each met their primary endpoint demonstrating a statistically-significant reduction in body weight.
The firm assessed the long-term efficacy and safety of velneperit over the course of one year in two double-blind, placebo-controlled studies, comprising a total randomized population of 1,566 obese subjects. Each trial assessed the drug under different reduced-calorie and low-calorie diet conditions.
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