Significant results for Shionogi obesity drug

2 March 2009

Japan's Shionogi says that two distinct year-long studies of velneperit, a novel neuropeptide Y (NPY) Y5 receptor antagonist also known as  S-2367, each met their primary endpoint demonstrating a  statistically-significant reduction in body weight.

The firm assessed the long-term efficacy and safety of velneperit over  the course of one year in two double-blind, placebo-controlled studies,  comprising a total randomized population of 1,566 obese subjects. Each  trial assessed the drug under different reduced-calorie and low-calorie  diet conditions.

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