Sonus' Tocosol misses Ph III endpoint, drug's future uncertain
Sonus Pharmaceuticals' Phase III pivotal trial of Tocosol Paclitaxel in women with metastatic breast cancer missed its primary endpoint of non-inferiority on objective response rate when compared to the Bristol-Myers Squibb's Taxol (paclitaxel) control arm. Trial results showed the ORR for Tocosol Paclitaxel was 37% versus 45% for Taxol (p=0.085). The outcome of this trial does not support the submission for US approval.
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