Strong new data on Trodelvy plus Keytruda survival in TNBC

22 April 2025

US biotech major Gilead Sciences (Nasdaq: GILD) today announced positive top-line results from the Phase III ASCENT-04/KEYNOTE-D19 study.

The trial demonstrated that Trodelvy (sacituzumab govitecan-hziy) plus Keytruda (pembrolizumab) significantly improved progression-free survival (PFS) compared to Keytruda and chemotherapy in patients with inoperable (unresectable) locally advanced or metastatic triple-negative breast cancer (mTNBC) whose tumors express PD-L1 (CPS ≥ 10). The study met its primary endpoint, showing a statistically significant and clinically meaningful improvement in PFS.

The results are welcome news for Gilead, which has been looking for a win for Trodelvy after two surprise trial failures early last year.

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