TorreyPines begins Ph I tezampanel trial
California, USA-based biopharmaceutical firm TorreyPines Therapeutics has begun a Phase I trial of its developmental migraine treatment tezampanel. The drug, which is an AMPA/kainate receptor antagonist, will be evaluated in terms of its safety, tolerability and pharmacokinetics.
In the study, 300 healthy volunteers will be provided with one of three subcutaneous doses of the drug (40mg, 70mg, 100mg), or placebo, once-daily for four consecutive days. The firm added that the same dosages are currently being examined in a Phase IIb trial in the treatment of acute migraine.
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