Vertex presents positive data for zimislecel in type 1 diabetes

23 June 2025

US drugmaker Vertex Pharmaceuticals (Nasdaq: VRTX) has announced simultaneous presentation and publication of updated data from the Phase I/II portion of the Phase I/II/III FORWARD-101 clinical trial of zimislecel (VX-880), an investigational stem cell-derived, fully differentiated islet cell therapy, in people with type 1 diabetes (T1D) with impaired hypoglycemic awareness and severe hypoglycemic events (SHEs).

The data were featured in an oral presentation at the American Diabetes Association (ADA) annual conference in Chicago as part of the symposium, “Innovation and Progress in Stem Cell-Derived Islet-Cell Replacement Therapy,” and published online by the New England Journal of Medicine.

Vertex obtained VX-880 as part of its buy of Semma Therapeutics for $950 million in 2019.

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