High-dose Wegovy cuts weight 21%, new data shows

21 June 2025

At a time when Novo Nordisk (NOVN: N) has appeared to be slipping behind rival Eli Lilly (NYSE: LLY) and its blockbuster Zepbound (tirzepatide) in the race to be the frontrunner in obesity, the Danish pharma major has fought back with some compelling data on its product Wegovy (semaglutide injection).

The company has presented the results from the Phase IIIb STEP UP trial for weight management in adults with obesity without diabetes at the American Diabetes Association (ADA) Scientific Sessions, in Chicago.

In the STEP UP trial, a higher, once-weekly 7.2mg dose of Wegovy, demonstrated a mean weight loss of 20.7%, with a third of participants losing 25% or more of their body weight compared to placebo at 72 weeks.

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