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One To Watch

OnCusp Therapeutics

A clinical-stage biopharma company developing treatments for cancer patients.

The company's lead program, CUSP06—a Cadherin-6 (CDH6)-targeting antibody-drug conjugate (ADC)—is in the Phase Ib portion of a Phase I study in patients with platinum-refractory/resistant ovarian cancer and other advanced solid tumors as of Q2 2025. 

OnCusp raised an oversubscribed $100 million Series A financing round in January 2024, co-led by Novo Holdings, OrbiMed, and F-Prime Capital. OnCusp is headquartered in Princeton, New Jersey.

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