Scientists believe that screening for prostate cancer using prostate specific antigen would lead to a substantial number of tumors diagnosed at an earlier and more treatable stage, however, there would be likely cases of overdiagnosed prostate cancer, according to a study published in the British Journal of Cancer.
The researchers studied 43,842 healthy men given PSA testing as part of the ProtecT study to calculate the number of advanced-stage prostate cancers picked up as a result of the testing. They also worked out the length of time during which prostate tumors do not produce symptoms but are detectable by a screening test - the mean sojourn time. The MST test is a method of calculating "overdiagnosis" and was used to estimate the probability of a diagnosis of prostate cancer that would not have caused symptoms during the patient's lifetime if screening had not taken place. There is no prostate cancer screening program in the UK but there is ongoing ad hoc testing. Screening with PSA alone is not yet recommended in the UK because there is not yet firm evidence that this reduces mortality from the disease.
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