No increase in CV events in Januvia trial
US pharma giant Merck & Co (NYSE: MRK) has announced the primary results of a placebo-controlled study of the cardiovascular safety of its DPP-4 inhibitor, Januvia (sitagliptin).
This already marketed drug generated first-quarter 2015 sales of $1.39 billion for Merck.
The Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) study achieved its primary composite CV endpoint of non-inferiority compared to usual care without sitagliptin. Non-inferiority was defined as the time to the first confirmed event of any of the following: CV-related death, nonfatal myocardial infarction (MI), nonfatal stroke, or hospitalization for unstable angina.
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