GD Searle, a wholly-owned subsidiary of Monsanto, has presented earlydata from two Phase III trials of its selective cyclo-oxygenase-2 inhibitor, celecoxib, for the treatment of arthritis pain.
Celecoxib is among the leaders in a series of new anti-inflammatory agents which selectively inhibit COX-2, the enzyme associated with inflammation, while having no effect on COX-1, the enzyme involved in the gastrointestinal side effects of non-steroidal anti-inflammatory drugs.
One 12-week Phase III study involved 1,004 patients with flare-ups of osteoarthritis of the knee. Patients received either placebo, naproxen 500mg bid, or one of three doses of celecoxib (50mg, 100mg or 200mg bid).
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