Boehringer Mannheim has received approval from the European Medicines Evaluation Agency for Bondronat/Bonviva (ibandronate), its bisphosphonate compound. The drug is indicated for the treatment of abnormally elevated serum calcium levels as a result of malignant tumors.
Clinical trials have shown that ibandronate effectively reduced serum calcium levels when administered as a single intravenous infusion over two hours in patients with tumor-related hypercalcemia. Clinical benefit in terms of the relief of unpleasant effects on the gastrointestinal tract and central nervous system usually associated with this disease have been demonstrated.
Rhone-Poulenc Rorer has worldwide comarketing rights to ibandronate under the terms of an agreement between the two companies forged in 1992.
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