ProCyte's Lead Product "No Better Than Placebo"

24 October 1994

ProCyte Corp of Seattle, USA, has been rocked by the news that its lead compound, a new product for the treatment of wounds, has proved to be ineffective in pivotal clinical trials. The company's share price reacted strongly to the news, falling 68% on the day of the announcement (Monday October 17).

Iamin Gel (PC1020; glycine-L-histidyl-L-lysine; copper complex) has completed Phase III testing in diabetic plantar wounds, but the results indicate that it is no better than placebo in treating these wounds.

The Phase III studies at 30 medical centers involved 511 people with diabetes and chronic ulcers on the plantar region of the foot. All patients in the study received aggressive wound care including debridement of the wound at study entry, pressure-relieving shoes and patient education. Patients were randomized to receive either 0.5% drug, 2% drug or placebo. The primary endpoints were the reduction in wound size and analysis of the number of patients who achieved full closure of their wound at the end of treatment. Secondary end-points included number of infections and time to healing.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK





Today's issue

Company Spotlight