Strong mouse data for AVI's NeuGene flu drugs

6 May 2007

Oregon, USA-based AVI BioPharma presented strong preclinical data demonstrating effectiveness of its NeuGene antisense compounds against seasonal influenza A virus in mice, at the 20th International Conference on Antiviral Research, held in Palm Springs, California, USA.

In experiments sponsored by AVI and conducted at Tulane University School of Medicine and the US Army Medical Research Institute for Infectious Diseases (USAMRIID), mice were pretreated with antisense phosphorodiamidate morpholino oligomers (PMOs), and then infected with two different strains of influenza A (H3N2 and H1N1). Treated mice showed significantly reduced clinical signs (weight loss) and increased survival compared to control-treated and untreated mice.

In addition, PMO-treated mice showed significantly reduced viral titer (to below limit of detection) in comparison to untreated mice. Histological examination of the lungs showed that treated mice had reduced pathology when examined for infiltrating cells or alveolar damage.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK





Today's issue

Company Spotlight