Strong Ph III data for Wyeth's RCC drug

11 June 2006

The USA's Wyeth Pharmaceuticals says that preliminary data from an interim analysis of an ongoing Phase III clinical trial of temsirolimus (CCI-779), its investigational drug for advanced renal cell carcinoma (RCC), showed that it significantly increased overall survival as a first-line treatment of patients with advanced disease and poor risk features, compared to interferon-alpha, a conventional treatment for this condition.

In data from the open-label, randomized, trial presented during a late-breaking plenary session at the annual meeting of the American Society of Clinical Oncology, held in Atlanta, Georgia, patients treated with the mTOR (mammalian target of rapamycin) inhibitor experienced a 3.6-month, or 49%, increase in median overall survival time compared with patients treated with interferon-alpha alone (10.9 months versus 7.3 months; p=0.0069).

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