TopoTarget and CuraGen's PXD101 in Ph I trial for solid tumors
Denmark's TopoTarget AS and USA-based CuraGen say they have initiated a Phase I clinical trial of PXD101 as a treatment for patients with solid tumors. The drug, which is a small-molecule histone deacetylase inhibitor, is also under assessment in a series of Phase II trials as a therapy for blood cancers (Marketletter August 9).
The Phase I solid-tumor study will be an open-label, multicenter assessment of the compound, which is designed to establish its maximum tolerated dose, safety and tolerability.
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