- Xenova and the UK Cancer Research Campaign have completed two Phase I trials for the anticancer drug XR5000, a topoisomerase I and II inhibitor for drug resistance in cancer. The trials involved 72 patients with advanced-stage cancer at centers in the UK and New Zealand. A maximun dose was established, and a good safety profile was seen, with the main side effect being dose-related pain from venous administration of the drug. Phase II will shortly begin in patients with other tumor types including glioblastoma.
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