Amgen files IND For Neurotrophin-3
Amgen has filed an Investigational New Drug application for neurotrophin-3 as a potential treatment for peripheral neuropathies on behalf of the Amgen-Regeneron partnership. The drug is being developed under a collaborative R&D agreement set up between the two companies in 1990.
NT-3 has been shown in animal and in vitro studies to have a specific stimulatory action on sensory neurons which enervate muscles. Amgen says it hopes that NT-3 will reduce the symptoms of peripheral neuropathy, such as weakness, numbness, tingling and loss of sensation. The condition often occurs in patients with diabetes and as a side effect of cytotoxic anticancer chemotherapy.
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