GeneMedicine's IL-2 Gene To Enter Phase I

17 February 1997

As was reported briefly in the Marketletter last week, GeneMedicine hasreceived clearance from the US Food and Drug Administration to begin Phase I clinical trials with its Interleukin-2 Cancer Gene Medicine for the treatment of head and neck cancer. The Investigational New Drug application was filed with the FDA in December 1996.

The trial, due to begin in the first half of this year, will investigate the safety and tolerability of the drug, which "is comprised of a plasmid encoding the human IL-2 gene and a proprietary non-viral gene delivery system," says the company. In animal models of head and neck cancer, the IL-2 gene therapy reduced the rate of tumor progression and increased survival.

The IND approval for the IL-2 gene therapeutic, the first product to result from GeneMedicine's collaboration with Boehringer Mannheim, sparks a $500,000 milestone payment from BM. Total research, development and equity funding to GeneMedicine could reach more than $47 million by the year 2000, it says.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK





Today's issue

Company Spotlight