British Biotech has advanced a second product into Phase III testing. Lexipafant, a platelet-activating factor (PAF) antagonist, has been entered into a pivotal trial involving 300 patients with acute pancreatitis in up to 15 hospitals in the UK. Primary study endpoints will be patient's organ failure score and the incidence of acute pancreatitis attacks, measured by local and systemic complications of the disease.
In September, British Biotech reported encouraging Phase II study results with lexipafant, which revealed a trend towards improvement in clinical severity and reduction in inflammation when measured by three surrogate markers of inflammation, interleukin-8, IL-6 and E-selectin.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2025 | Headless Content Management with Blaze