Trials Show Efficacy Of Wyeth's Rotavirus Vaccine

29 October 1997

The largest efficacy trial of a rotavirus vaccine in a developingcountry to date has shown that Wyeth-Ayerst's rhesus rotavirus-based quadrivalent oral vaccine reduced severe diarrhea by 88% in 2,207 infants in Venezuela. Data from the trial are reported in the New England Journal of Medicine (October 23 issue).

Rotavirus diarrhea affects 130 million infants and children every year throughout the world, resulting in 873,000 deaths, only 75-150 of these being in the USA.

Although the vaccine has shown high efficacy in preventing severe diarrhea in developed countries (in two studies in the USA and one in Finland, to be discussed later), with protection rates of 80%-91%, its efficacy in the developing world has been less impressive (with a protection rate of 30%-46%), according to the study authors, who included Albert Kapikian from the US National Institute of Allergy and Infectious Diseases, where the vaccine was developed.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK



Companies featured in this story

More ones to watch >


Today's issue

Company Spotlight