Roche's R1507 effective at Ph I against solid tumors

5 November 2007

Swiss drug major Roche says that Phase I data from a trial of R1507, a monoclonal antibody that targets the insulin-like growth factor receptor (IGF-1R), demonstrate that the agent has therapeutic efficacy against solid tumors. The firm said that the finding is significant because IGF-1R has been shown to play a role in both tumor proliferation and the development of drug resistance.

Data from the study, which were presented at the joint meeting of the American Association of Cancer Research, the National Cancer Institute and the European Organization for the Research and Treatment of Cancer in San Francisco, showed that nine of the 34 patients who received weekly treatment demonstrated disease stabilization. In addition, four subjects suffering from Ewing's sarcoma, a form of cancer for which there are few currently-available therapeutic options, received clinical benefit and, in two cases, achieved objective partial responses.

The study also showed that R1507 was associated with very few side effects, and had not caused some of the adverse events (low blood cell count, infection, hair loss, nausea and vomiting) common with other cancer therapies. Adverse events that were observed included fatigue, anorexia and weight loss, all of which are often seen in patients with advanced cancers.

This article is accessible to registered users, to continue reading please register for free.  A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.

Login to your account

Become a subscriber

 

£820

Or £77 per month

Subscribe Now
  • Unfettered access to industry-leading news, commentary and analysis in pharma and biotech.
  • Updates from clinical trials, conferences, M&A, licensing, financing, regulation, patents & legal, executive appointments, commercial strategy and financial results.
  • Daily roundup of key events in pharma and biotech.
  • Monthly in-depth briefings on Boardroom appointments and M&A news.
  • Choose from a cost-effective annual package or a flexible monthly subscription
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed

Chairman, Sanofi Aventis UK



Companies featured in this story

More ones to watch >


Today's issue

Company Spotlight