Onyx Pharmaceuticals and Bayer have reported Phase I clinical resultswith BAY-43-9006, claimed to be the first orally-active Raf kinase inhibitor to undergo clinical testing. The drug blocks the Ras signaling pathway in cells, which is believed to play a role in around 30% of all human tumors. The 12-patient study looked at single, escalating doses of the drug, ranging from 50mg to 400mg given once-weekly, and found no significant toxicities. Preclinical data have shown that the drug can inhibit a wide range of tumor xenograft models.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2025 | Headless Content Management with Blaze