Genmab regains HuMax-CD4 rights
Denmark's Genmab says it has regained all rights to the HuMax-CD4 (zanolimumab) antibody from Merck Serono SA, which were licensed to the firm in August 2005. Genmab plans to continue moving development of HuMax-CD4 forward in the existing non-cutaneous T-cell lymphoma and cutaneous T-cell lymphoma clinical programs and expand development into earlier stage patients in combination with PUVA as well as other combinations with approved therapies for CTCL.
Genmab is also making plans to develop a UniBody targeting the CD4 receptor. HuMax-CD4 binds the CD4 molecule with very high affinity and effectively blocked and neutralized infection of a broad panel of HIV-1 viruses isolated from infected individuals. Laboratory studies in an immunodeficient mouse model showed HuMax-CD4 to effectively block HIV-1 replication and reduce depletion of CD4+ T-cells by the virus, the firm noted.
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