Keros Thera slumps after halting parts of cibotercept trial
US clinical-stage drug developer Keros Therapeutics’ (Nasdaq: KROS) shares plummeted more than 73% to $18.20 in pre-market activity on revealing a setback for a lead investigational candidate.
Keros today announced that it has voluntarily halted dosing in the 3.0 mg/kg and 4.5 mg/kg treatment arms in the ongoing TROPOS trial, a Phase II clinical trial of cibotercept (KER-012) in combination with background therapy in patients with pulmonary arterial hypertension (PAH). It said that the decision was made based on a safety review due to the unanticipated observation of pericardial effusion adverse events in the trial.
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