Merck & Co's fibrinogen receptor antagonist Aggrastat (MK-383) was unable to improve outcomes after coronary angioplasty, when added to standard therapy, in a Phase III trial presented at the American College of Cardiology meeting.
At 30 days after the procedure, Aggrastat combined with heparin and aspirin reduced the combined endpoint of death, nonfatal heart attack and revascularization procedures by 16% compared with aspirin and heparin alone, but this difference failed to reach statistical significance.
Nevertheless, Merck noted that a statistically-significant reduction was observed throughout the first seven days after angioplasty which was encouraging. Final results from this study, as well as results from another trial in unstable angina patients, should be available next year.
This article is accessible to registered users, to continue reading please register for free. A free trial will give you access to exclusive features, interviews, round-ups and commentary from the sharpest minds in the pharmaceutical and biotechnology space for a week. If you are already a registered user please login. If your trial has come to an end, you can subscribe here.
Login to your accountTry before you buy
7 day trial access
Become a subscriber
Or £77 per month
The Pharma Letter is an extremely useful and valuable Life Sciences service that brings together a daily update on performance people and products. It’s part of the key information for keeping me informed
Chairman, Sanofi Aventis UK
Copyright © The Pharma Letter 2025 | Headless Content Management with Blaze