ASH 2024: Adding to Calquence to venetoclax improves PFS in CLL

9 December 2024

Positive results from the AMPLIFY Phase III trial have shown that adding AstraZeneca’s (LSE: AZN) Calquence (acalabrutinib) to venetoclax led to a statistically-significant and clinically-meaningful improvement in progression-free survival (PFS) compared to standard-of-care chemoimmunotherapy in previously untreated adult patients with chronic lymphocytic leukaemia (CLL).

The results are being presented at the ongoing American Society of Hematology (ASH) 2024 Annual Meeting in San Diego, California.

Calquence is a second-generation, selective inhibitor of Bruton’s tyrosine kinase (BTK), while venetoclax is a BCL-2 inhibitor also known by the brand names Venclexta and Venclyxto and marketed by AbbVie (NYSE: ABBV) and Roche (ROG: SIX).

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