- Owen Healthcare, a hospital pharmacy benefit manager in the USA, has removed Hoffmann-La Roche's Toradol (ketorolac) from pre- and postoperative settings in response to "recent manufacturer labelling changes." Owen said that the labelling changes mean that Toradol is now contraindicated in the following areas: as a prophylactic analgesic before major surgery; for use during surgery; for use in labor and delivery; in patients with a history of active peptic ulcer disease; advanced renal impairment; for epidural or intrathecal administration; in combination with other nonsteroidal anti-inflammatories; or hypersensitivity to aspirin. Roche suggested that restricting the use of Toradol may prevent doctors from prescribing the drug as an alternative to opioids.
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