Unexpected Phase III miss for novel asthma candidate

22 December 2020

British drugmaker AstraZeneca (LSE: AZN) and USA-based Amgen (Nasdaq: AMGN) have announced negative results from the Phase III SOURCE trial of tezepelumab.

The trial compares the potential first-in-class medicine with placebo in 150 severe asthma patients who required maintenance use of oral corticosteroids (OCS).

The 48-week trial did not meet the primary endpoint of a statistically-significant reduction in the daily OCS dose, without loss of asthma control.

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